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the teeth shall not set forth. Such is well. For a detailed overview of the study and participating sites see below. The purpose of this study is to collect 600 blood samples and 210 cerebrospinal fluid , pure lower or upper motor neuron diseases, other neurodegenerative diseases, as well as healthy volunteers. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to diagnose ALS and monitor disease progression. Researchers tested what changes happen in volunteers with ALS that can be seen in the blood and what changes are unique to ALS and are different from those found in healthy volunteers and volunteers with neurological diseases other than ALS. These changes are called biomarkers. Biomarkers for ALS have been found in blood collected in earlier phases of this study. Biomarkers are non-genetic elements in your blood that may help to make diagnosing ALS easier. In the next phase, comparison of these changes in the blood of volunteers with ALS and without ALS will be used to confirm these biomarkers and to develop a tool to diagnose and monitor progression of ALS. Volunteers will be enrolled into 1 of 4 groups. Volunteers may have their blood drawn up to 3 times and may have cerebrospinal fluid drawn once. The researchers will collect information on your diagnosis, vital signs, medical history and medications, as well as contact you by telephone up to 3 times. 600 blood samples will be collected from four groups: ALS volunteers diagnosed with ALS, volunteers with pure lower or pure upper motor neuron diseases, volunteers with other neurological diseases and healthy control volunteers. 210 cerebrospinal fluid samples will be collected from a group of volunteers with in the ALS, pure lower or pure upper motor neuron diseases, and other neurological diseases. RECRUITMENT STATUS: The study is currently open to recruitment. The NCTU Coordination Center IRB Approval: January 2, 2008. Site IRB Approvals on ongoing basis.. Advair Diskus relaxes muscles in your lungs to open airways and make breathing easier. It can take time for a drug to start working, or for some side effects to go away. There are reports of worsening asthma leading to death in people taking Advair Diskus should only be used if your symptoms have not improved with a fast-acting or controller medication alone. If this happens, call 911 or your doctor right away. This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider. Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor..

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